Fig. 3
From: Age-dependent inflammatory response is altered in an ex vivo model of bacterial pneumonia
Expression of receptors associated with immune cell chemotaxis are age-dependently regulated. PCLS of young and old mice were infected with 1 × 105 CFU/well PAO1 or D61 or cultured without bacteria (Ctrl). Whole genome analysis was performed 8 h p.i. Differentially regulated genes (≥ 2-fold change, p < 0.05) were analyzed in DAVID for enrichment analysis of biological process ontology and signal intensity of chosen genes encoding for receptors associated with ‘neutrophil chemotaxis’ are shown. * p < 0.05, ** p < 0.01, *** p < 0.001 compared with respective control (Ctrl) within one age group. # p < 0.05, ## p < 0.01, ### p < 0.001, between the two age groups, based on the p-value analyzed using the Transcriptome Analysis Console Software (TAC 4.0, Thermo Fisher Scientific). All other conditions are not significant