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Table 6 Adjusted mean effects of liver diseases on liver transaminases, LDL cholesterol and total cholesterol. Confounding factors include age, gender and nicotine abuse

From: Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning

Biomarker

*Mean Difference

Lower CI

Upper CI

p-value

AATD (n = 170)

    

 ALAT

-76.07

-105.49

-46.64

< 0.001

 ASAT

-164.55

-259.93

-69.17

< 0.001

 LDL

9.86

7.08

12.65

< 0.001

 Total cholesterol

16.08

9.15

23.01

< 0.001

Non-AATD (n = 3228)

 ALAT

-35.34

-54.94

-15.73

< 0.001

 ASAT

-96.47

-174.85

-18.09

0.016

 LDL

31.01

-5.62

67.63

0.097

 Total cholesterol

34.76

-18.98

88.51

0.205

COPD (n = 3398)

 ALAT

-85.12

-114.84

-55.55

< 0.001

 ASAT

-192.88

-289.86

-95.91

< 0.001

 LDL

9.79

5.70

13.88

< 0.001

 Total cholesterol

16.04

8.38

23.70

< 0.001

  1. * In this table, the difference is comparing transaminases between individuals without liver disease and those with liver disease. ASAT: Aspartate Aminotransferase, ALAT: Alanine Aminotransferase, LDL: Low Density Lipoprotein