Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning

Table 5 Table assessing the influence of hs-troponin on predicting hospital mortality

	Estimate	OR	lower.CI	upper.CI	p- value
AATD (n = 68)
Gender (Ref: Male)	-0.38	0.68	-1.63	0.87	0.552
Age	0.06	1.07	0.01	0.12	0.029
Nicotine abuse (Ref: Non-smoker)	1.39	4.04	-0.62	3,41	0,174
Hs-troponin	2.29	9.93	-2.33	6.92	0.330
Non AATD (n = 3465)
Gender (Ref: Male)	0.05	1.05	-0.09	0.18	0.489
Age	0.01	1.02	0.01	0,02	< 0.001
Nicotine abuse (Ref: Non-smoker)	-0.13	0.88	-0.31	0,05	0.157
Hs-troponin	0.62	1.85	0.26	0.97	< 0.001
All COPD (n = 3533)
Gender (Ref: Male)	0.04	1.04	-0.09	0.17	0.525
Age	0.02	1.02	0.01	0.02	< 0.001
Nicotine abuse (Ref: Non-smoker)	-0.11	0.9	-0.29	0.07	0.220
AATD(Ref: Non-AATD)	0.82	2.26	0.17	1.46	0.012
Hs-troponin	0.62	1.85	0.26	0.97	< 0.001
AATD: hs-troponin	1.80	6.07	-2.42	6.03	0.403

This model was fitted using pooled data from the Site A and Site E cohorts only. AATD: Alpha 1-antitrypsin deficiency, hs-troponin: high sensitivity troponin

ISSN: 1465-993X