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Fig. 8 | Respiratory Research

Fig. 8

From: METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway

Fig. 8

TGF-β1 induces the differentiation of LR-MSCs into myofibroblasts by modulating the METTL3/miR-21/PTEN pathway. A, B The mRNA and protein expression levels of PTEN in LR-MSCs with or without METTL3 silencing, combined with or without treatment with TGF-β1 and miR-21 mimics. C–E The mRNA and protein expression levels of myofibroblast markers (α-SMA, type I collagen, and vimentin) in LR-MSCs with or without METTL3 silencing, PTEN overexpression, and treatment with TGF-β1 and miR-21 mimics. β-Actin was used as a reference gene. Scale bars = 20 μm, **P < 0.01

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Respiratory Research

ISSN: 1465-993X

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