| Pre-BT | Post-BT | p-value |
---|---|---|---|
Number of subjects | 20 | 20 | Â |
Months since BT* | – | 23 (15) |  |
Age (years)†| 47 ± 2 | 49 ± 2 |  |
Sex (M/F) | 8/12 | 8/12 | Â |
Smoking status (no/ex/yes) | 13/6/1 | 13/6/1 | Â |
Atopy (no/yes) | 6/14 | 6/14 | Â |
Inhaled corticosteroid dose (µg)†,§ | 1275 ± 175 | 938 ± 166 | 0.035 |
Median (range) | 1375 (0–3000) | 750 (0–3000) |  |
Long acting β2-agonist (µg)†,ll | 114 ± 14 | 102 ± 13 | 0.45 |
Median (range) | 100 (0–250) | 100 (0–200) |  |
Oral corticosteroids (n) | 4 (7.5–30.0) | 3 (5.0–10.0) | 0.25 |
Omalizumab (n) | 3 | 3 | > 0.99 |
Mepolizumab (n) | 1 | 2 | 0.60 |
Montelukast (n) | 9 | 8 | > 0.99 |
Post-BD FEV1 (L)†| 2.66 ± 0.18 | 2.83 ± 0.19 | 0.17 |
Count of severe exacerbations‡ | 1 (0–10) | 0 (0–2) | 0.019 |
ACSS†| 71 ± 4 | 88 ± 3 | 0.0004 |