Fig. 1 

Transcriptomic analysis of BECs of severe asthmatics pre- and post-BT measured using microarray. A Volcano plot showing the distribution of transcript expression P values and fold changes. All transcripts were tested using the transcriptome analysis console (TAC) software. B Heat map. The molecular signatures pre-BT and post-BT were visualized by hierarchical clustering based on the differential transcripts’ expression. C Interaction network constructed using the ingenuity pathway analysis software. Nodes shaded in pink or red represent genes that are upregulated, and blue nodes are downregulated post-BT. A solid line represents a direct interaction and a dotted line an indirect interaction. D Several S100A family genes were interconnected in the same network in the post-BT signature. The color intensity indicates the degrees of up-regulation or down-regulation