Table 4 Effect size of MCC950 on IL-1β secretion from peripheral blood mononuclear cells

Media

(2 h)

Mean diff. (95% CI)

− 0.3

(− 1.1 to 0.5)

0.3

(− 1.0 to 1.6)

0.5

(− 0.7 to 1.8)

0.1

(− 1.5 to 1.7)

P value

0.5016

0.6882

0.3812

0.9070

LPS

(2 h)

Mean diff. (95% CI)

− 13.5

(− 40.2 to 13.3)

− 28.2

(− 59.2 to 2.8)

− 14.7

(− 51.8 to 22.3)

− 68.8

(− 178.6 to 41.0)

P value

0.3244

0.0755

0.4355

0.2202

Nigericin (1 h)

Mean diff. (95% CI)

− 32.2

(− 120.9 to 56.5)

− 113.9

(− 213.6 to − 14.2)

− 81.7

(− 162.7 to − 0.8)

− 76.0

(− 251.7 to 99.7)

P value

0.4773

0.0256

0.0484

0.3970

LPS (2 h) + Nigericin (1 h)

Mean diff. (95% CI)

240.2

(− 412.3 to 892.7)

− 1380.9

(− 2399.2 to − 362.5)

− 1621.0

(− 2589.7 to

− 652.4)

− 937.6

(− 2363.3 to 488.1)

P value

0.4710

0.0082

0.0011

0.1981

Media

(4 h)

Mean diff. (95% CI)

− 2.4

(− 11.6 to 6.8)

2.2

(− 0.9 to 5.4)

4.6

(− 4.0 to 13.3)

1.5

(− 0.4 to 3.5)

P value

0.6096

0.1600

0.2948

0.1293

LPS

(4 h)

Mean diff. (95% CI)

− 30.3

(− 74.4 to 13.8)

− 66.8

(− 128.9 to − 4.7)

− 36.5

(− 99.4 to 26.4)

29.5

(− 87.9 to 146.8)

P value

0.1783

0.0357

0.2560

0.6229

Nigericin

(1 h)

Mean diff. (95% CI)

− 73.6

(− 118.2 to − 29.1)

− 99.7

(− 143.4 to − 56.1)

− 26.1

(− 86.0 to 33.8)

62.0

(− 109.8 to 233.8)

P value

0.0013

 < 0.0001

0.3933

0.4799

LPS (4 h) + Nigericin (1 h)

Mean diff. (95% CI)

− 79.3

(− 1646.5 to 1487.9)

− 3735.3

(− 6046.7 to − 1423.8)

− 3655.9

(− 5915.2 to

− 1396.7)

103.4

(38.1 to 168.8)

P value

0.9210

0.0016

0.0016

0.0020