Table 3 LPS + Nigericin stimulation of peripheral blood mononuclear cells from patients with severe asthma, Spearman correlation coefficients between IL-1β release and key clinical characteristics
From: Characterization and inhibition of inflammasome responses in severe and non-severe asthma
LPS (2 h) + Nigericin (1 h) | LPS (4 h) + Nigericin (1 h) | |||
|---|---|---|---|---|
BMI | r = − 0.13 | P = 0.436 | r = − 0.27 | P = 0.113 |
ACQ-6, mean | r = 0.12 | P = 0.489 | r = − 0.00 | P = 0.980 |
Sputum eosinophils, % | r = − 0.17 | P = 0.456 | r = 0.26 | P = 0.247 |
Sputum eosinophils, total | r = 0.46 | P = 0.043 | r = 0.55 | P = 0.012 |
Sputum neutrophils, % | r = 0.40 | P = 0.067 | r = 0.18 | P = 0.415 |
Sputum neutrophils, total | r = 0.48 | P = 0.032 | r = 0.33 | P = 0.158 |
FEV1preb2pp | r = 0.17 | P = 0.339 | r = 0.12 | P = 0.478 |
FVCpreb2pp | r = 0.13 | P = 0.473 | r = 0.14 | P = 0.435 |
FEV1/FVC, % | r = 1.00 | P = 0.568 | r = 0.06 | P = 0.741 |