Table 2 Nigericin stimulation of peripheral blood mononuclear cells from patients with severe and non-severe asthma, Spearman correlation coefficients between IL-1β release and key clinical characteristics
From: Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Media (2 h) + Nigericin (1 h) | Media (4 h) + Nigericin (1 h) | |||
|---|---|---|---|---|
BMI | r = − 0.14 | P = 0.190 | r = − 0.11 | P = 0.299 |
ACQ-6, mean | r = 0.12 | P = 0.258 | r = 0.01 | P = 0.892 |
Sputum eosinophils, % | r = − 0.11 | P = 0.398 | r = 0.05 | P = 0.681 |
Sputum eosinophils total | r = 0.12 | P = 0.352 | r = 0.15 | P = 0.253 |
Sputum neutrophils, % | r = 0.27 | P = 0.030 | r = 0.39 | P = 0.001 |
Sputum neutrophils, total | r = 0.35 | P = 0.006 | r = 0.39 | P = 0.002 |
FEV1preb2pp | r = − 0.24 | P = 0.022 | r = − 0.18 | P = 0.088 |
FVCpreb2pp | r = − 0.21 | P = 0.041 | r = − 0.17 | P = 0.095 |
FEV1/FVC, % | r = − 0.11 | P = 0.303 | r = − 0.16 | P = 0.130 |