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Table 1 Spirometry (n = 200), DLCO (n = 194) and SPB (n = 194) values in patients with post COVID syndrome

From: Symptomatic post COVID patients have impaired alveolar capillary membrane function and high VE/VCO2

 

CP disease  + (n 55)

CP disease − (n 143)

CT > 7.2% (n 51)

CT <  = 7.2% (n 99)

peak VO2 < 80% (n 97)

peak VO2 > 80% (n 96)

VE/VCO2 > 120% (n 67)

VE/VCO2 < 120% (n 126)

Age (years)

53.8 ± 13.1

63.1 ± 16.1*

61.6 ± 13.2

54.1 ± 14.9*

53.2 ± 13.1

58.0 ± 14.8#

56.1 ± 16.0

54.9 ± 12.8

Gender (males)

37 (67%)

73 (51%)

29 (57%)

52 (53%)

62 (64%)

37 (36%)

37 (55%)

73 (58%)

BMI (kg/m2)

25.5 ± 3.8

25.9 ± 4.2

27.3 ± 3.9

25.1 ± 3.8*

26.1 ± 4.3

25.5 ± 3.6

26.3 ± 4.7

25.6 ± 3.6

SPB (AU)

84.0 [50.0–124.3]

66.1 [44.0–90.7]*

71.1 [52.5–114.2]

66.6 [47.7–88.4]

72.3 [48.5–110.6]

64.7 [43.6–84.6]#

69.2 [49.9–108.0]

67.0 [44.9–92.4]

FVC (%)

94 ± 19

101 ± 16*

93 ± 17

103 ± 17*

96 ± 17

104 ± 15*

97 ± 18

102 ± 16#

FEV1(%)

93 ± 20

101 ± 16*

95 ± 17

101 ± 16#

97 ± 17

104 ± 16*

97 ± 18

102 ± 15

FEV1/FVC

86.7 ± 15.9

86.2 ± 13.0

83.6 ± 14.5

88.6 ± 14.4§

85.2 ± 14.2

88.7 ± 13.1

85.2 ± 14. 8

87.7 ± 13.1

DLCO (mL/min/mmHg)

21.2 ± 7.2

22.3 ± 6.6

19. 8 ± 5.9

23.0 ± 6.7*

21.9 ± 7.2

22.9 ± 6.0

20.8 ± 6.7

23.3 ± 6.5#

DLCO (%)

80 ± 20

82 ± 19

77 ± 16

85 ± 20*

79 ± 21

86 ± 15#

77 ± 18

85 ± 18*

DLNO (mL/min/mmHg)

91.3 ± 32.9

95.2 ± 28.2

82.1 ± 26.5

99.7 ± 28.6*

93.3 ± 29.5

98.4 ± 28.0

91.2 ± 27.9

99.3 ± 28.1

DM (mL/min/mmHg)

45.5 ± 17.1

47.8 ± 13.7

41.5 ± 13.4

50.4 ± 14.3*

46.4 ± 15.4

49.8 ± 13.2

45.6 ± 15.0

49.5 ± 14.0

DM (%)

101 ± 23

107 ± 22

95 ± 20

113 ± 23*

102 ± 24

112 ± 20*

102 ± 22

110 ± 22#

Vcap (mL)

57 ± 18

60 ± 17

54 ± 17

62 ± 15*

58 ± 18

62 ± 15#

56 ± 18

62 ± 15#

Vcap (%)

82 ± 23

86 ± 22

81 ± 21

89 ± 22§

82 ± 23

88 ± 19

80 ± 22

88 ± 20#

VA (L)

5.2 [4.4–5.8]

5.2 [4.5–5.9]

5.0 [4.1–5.6]

5.3 [4.4–6.1]@

5.2 [4.5–6.2]

5.3 [4.5–5.8]

5.0 [4.3–5.8]

5.4 [4.6–6.2]

  1. SPB: surfactant binding protein; AU: arbitrary unit; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lungs for carbon monoxide (data corrected for hemoglobin); DLNO: diffusing capacity of the lungs for nitric oxide; DM: membrane diffusion; Vcap: capillary volume; VA: alveolar volume; CP disease: history of cardiopulmonary diseases; CT: thoracic computer tomography; peak VO2: peak oxygen intake; VE/VCO2: minute ventilation/carbon dioxide production relationship. *p < 0.01; #p < 0.05; §p = 0.05; @p = 0.06