Table 4 Hazard ratios for time to the composite outcome (non-fatal severe CV event or all-cause death), comparing exposed periods in the 365 days following a first, second, and third exacerbation of COPD to the non-exposure period
Time period | No. of first CV events of any type | Person years of follow-up | Unadjusted HR (95% CI) | Adjusted* HR (95% CI) |
|---|---|---|---|---|
After the onset of the first exacerbation (moderate or severe) | ||||
1–7 days | 33 | 43 | 20.0 (13.7–29.4) | 15.2 (10.3–22.4) |
8–14 days | 20 | 42 | 12.1 (7.5–19.5) | 9.3 (5.8–15.1) |
15–30 days | 16 | 91 | 4.9 (3.0–8.2) | 3.9 (2.3–6.4) |
31–180 days | 49 | 704 | 2.0 (1.5–2.7) | 1.6 (1.2–2.2) |
181–365 days | 38 | 640 | 1.8 (1.3–2.5) | 1.5 (1.1–2.1) |
After the onset of the second exacerbation (moderate or severe) | ||||
1–7 days | 21 | 20 | 30.9 (20.0–47.7) | 22.3 (14.3–34.6) |
8–14 days | 6 | 20 | 8.9 (4.0–20.0) | 6.5 (2.9–14.6) |
15–30 days | 9 | 43 | 6.2 (3.2–12.0) | 4.6 (2.4–8.9) |
31–180 days | 31 | 289 | 3.3 (2.3–4.7) | 2.6 (1.8–3.7) |
181–365 days | 12 | 226 | 1.6 (0.9–2.9) | 1.3 (0.7–2.3) |
After the onset of the third exacerbation (moderate or severe) | ||||
1–7 days | 10 | 11 | 28.2 (15.1–52.7) | 20.2 (10.7–38.0) |
8–14 days | 3 | 11 | 8.5 (2.7–26.4) | 5.8 (1.9–18.0) |
15–30 days | 7 | 23 | 9.3 (4.4–19.6) | 6.6 (3.1–13.9) |
31–180 days | 15 | 148 | 3.1 (1.9–5.2) | 2.3 (1.4–3.9) |
181–365 days | 7 | 96 | 2.3 (1.1–4.8) | 1.6 (0.8–3.5) |