Fig. 9
From: Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9
Krt15+ cells transform into AT2 cells to protect alveoli. A Immunofluorescence staining of lung tissue with Krt15 (Red) and Sftpc (Green). B The ratio of Krt15+Sftpc+ cells/Total cells. C Staining-intensity profiles showing signals from three fluorescent channels. D The ratio of TUNEL+ cells/Total cells. E TUNEL staining. N = 3 in each group.*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. R26mT-60d, Krt15-CrePGR;Rosa26-LSL-tdTomato mice exposed to air on days 60; R26mTCS-14d, R26mTCS-30d R26mTCS-60d, Krt15-CrePGR; Rosa26-LSL-tdTomato mice exposed to CS (on days 14, 30, and 60). WT wild-type, WT CS wild-type + CS exposure, Krt15−/− Krt15 knockout mice, Krt15−/− CS Krt15 knockout mice + CS exposure, CS cigarette smoking. The arrows point to TUNEL+ cells