Fig. 6
From: Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9
Inhibition of MMP9 alleviated the exacerbation of lung injury and inflammation caused by Krt15 knockdown in CS-exposed mice. A H&E and IHC stainings of Krt15, MMP-9, E-cadherin, and Vimentin. B The concentration of IL-6 (B); IL-1β (C); and TNF-α (D) in BALF. **p < 0.01, ****p < 0.0001. WT wild-type, WT CS wild-type mice + CS exposure, AdKrt15 CS wild-type mice + 60 mL adenovirus (5 × 1010 pfu/mL) + CS, AdKrt15 CS + SB-3CT wild-type mice + 60 mL adenovirus + CS + SB-3CT, CS cigarette smoking, SB-3CT an inhabitor of MMP-9