Fig. 1
From: Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9
Expression of Krt15 in humans and mice. A and B Comparison of expression of Krt15 in nonsmokers and patients with COPD in GSE5058 and GSE8545 datasets obtained from the Gene Expression Omnibus database. C Immunofluorescence intensity of Tomato+ (Krt15+) cells (Red) in Krt15-CrePGR;Rosa26-LSL-tdTomato reporter mice; 4',6-diamidino-2-phenylindole (DAPI) was used to stain nuclei. D The intensity of Krt15+; N = 3 in each group.*p < 0.05; **p < 0.01; ***p < 0.001. R26mT-14d, R26mT-30d, R26mT-60d, Krt15-CrePGR;Rosa26-LSL-tdTomato mice exposed to air on days 14, 30, and 60; R26mTCS-14d, R26mTCS-30d, R26mTCS-60d, Krt15-CrePGR;Rosa26-LSL-tdTomato mice exposed to CS (on days 14, 30, and 60)