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Table 6 Baseline FVC and changes in FVC at Week 48 by emphysema extent < 15%/≥ 15%

From: A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema

Predicted emphysema extent

Clinical trial cohort (N = 455)

N

Median predicted emphysema extent,%

Mean (SD) FVC, L

Change in mean (SD) FVC frombaseline

Relative, %

Absolute, L

Baseline

455

8.4

2.80 (0.78)

–

–

< 15%

372

6.7

2.71 (0.74)

–

–

≥ 15%

83

19.5

3.20 (0.82)

–

–

Week 48

443

9.0

2.69 (0.83)

–5.4 (12.1)

–0.14 (0.34)

< 15%

349

7.1

2.56 (0.75)

–6.3 (12.0)

–0.16 (0.31)

≥ 15%

94

19.9

3.14 (0.95)

–1.4 (11.8)

–0.04 (0.41)

    

P = 0.0008*

P = 0.0105‡

  1. Baseline FVC (L) and changes from baseline in relative (%) and absolute (L) FVC at Week 48 by emphysema extent < 15% and ≥ 15% for patients with IPF, with and without emphysema, in the clinical trial cohort (N = 455)
  2. FVC forced vital capacity; IPF idiopathic pulmonary fibrosis; SD standard deviation
  3. * Comparison of change in FVC from baseline to Week 48 between the < 15% and ≥ 15% baseline-predicted emphysema extent groups using a t-test with equal variance
  4. ‡ Comparison of change in FVC from baseline to Week 48 between the < 15% and ≥ 15% baseline-predicted emphysema extent groups using a t-test with unequal variance
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Respiratory Research

ISSN: 1465-993X

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