Table 4 Linear mixed-effect models for change in FVC over 48 weeks using CPFE dichotomous at 15%
From: A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema
Clinical trial cohort (N = 455) | ||||
|---|---|---|---|---|
Relative change in FVC (%) | Absolute change in FVC (L) | |||
Coefficient | P-value | Coefficient | P-value | |
Model A | ||||
CPFE formula ≥ 15% | 2.43 | 0.0009 | 0.06 | 0.0024 |
Months | –0.11 | < 0.0001 | –0.003 | < 0.0001 |
Model B | ||||
CPFE formula ≥ 15% | 1.61 | 0.0048 | 0.04 | 0.0027 |
Months | –10.90 | < 0.0001 | –0.003 | < 0.0001 |
ILD extent | –0.05 | 0.0033 | –0.001 | 0.0053 |
Male | –0.35 | 0.48 | –0.02 | 0.16 |
Age | 0.03 | 0.22 | 0.001 | 0.19 |
Current/former smoker | 0.29 | 0.56 | 0.01 | 0.58 |
Model C | ||||
CPFE formula ≥ 15% | 1.98 | 0.0045 | 0.06 | 0.0016 |
Months | –0.11 | < 0.0001 | –0.003 | < 0.0001 |
ILD extent | –0.04 | 0.0138 | –0.001 | 0.0262 |
Male | –0.34 | 0.49 | –0.02 | 0.16 |
Age | 0.03 | 0.24 | 0.001 | 0.21 |
Current/former smoker | 0.27 | 0.59 | 0.01 | 0.62 |
CPFE formula x ILD extent | –0.001 | 0.35 | 0.0000 | 0.21 |