Table 3 Linear mixed-effect models for change in FVC over time
From: A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema
Clinical trial cohort (N = 455) | Real-world cohort* (N = 124) | |||||||
|---|---|---|---|---|---|---|---|---|
Relative FVC change (%) | Absolute FVC change (L) | Relative FVC change (%) | Absolute FVC change (L) | |||||
Coefficient | P-value | Coefficient | P-value | Coefficient | P-value | Coefficient | P-value | |
Model A | ||||||||
CPFE formula | 0.0646 | < 0.0001 | 0.0012 | 0.2445 | 0.0025 | 0.3708 | 0.0048 | 0.3686 |
Months‡ | –0.1143 | < 0.0001 | –0.0030 | < 0.0001 | –0.0042 | < 0.0001 | –0.0108 | 0.0000 |
Model B | ||||||||
CPFE formula | 0.0362 | 0.2564 | 0.0009 | 0.2934 | 0.0007 | 0.7964 | 0.0020 | 0.7061 |
Months‡ | –0.1087 | < 0.0001 | –0.0026 | < 0.0001 | –0.0042 | < 0.0001 | –0.0108 | 0.0000 |
ILD extent | –0.0533 | 0.0012 | –0.0013 | 0.0016 | 0.0045 | 0.0221 | 0.0064 | 0.0781 |
Male | –0.4328 | 0.3787 | –0.0203 | 0.1111 | –0.1087 | 0.0583 | –0.1681 | 0.1121 |
Age | 0.0312 | 0.2410 | 0.0009 | 0.2115 | 0.0058 | 0.0112 | 0.0145 | 0.0005 |
Current/former smoker | 0.3737 | 0.4488 | 0.0093 | 0.4627 | 0.0935 | 0.0340 | 0.1134 | 0.1652 |
Model C | ||||||||
CPFE formula | 0.0841 | 0.3546 | 0.0025 | 0.2832 | –0.0214 | 0.0259 | –0.0333 | 0.0649 |
Months‡ | –0.1085 | < 0.0001 | –0.0026 | < 0.0001 | –0.0042 | < 0.0001 | –0.0108 | 0.0000 |
ILD extent | –0.0425 | 0.0920 | –0.0010 | 0.1370 | 0.0004 | 0.8762 | –0.0001 | 0.9858 |
Male | –0.4327 | 0.3791 | –0.0203 | 0.1114 | –0.1099 | 0.0501 | –0.1696 | 0.1033 |
Age | 0.0310 | 0.2440 | 0.0009 | 0.2150 | 0.0062 | 0.0055 | 0.0152 | 0.0002 |
Current/former smoker | 0.3861 | 0.4340 | 0.0098 | 0.4423 | 0.0907 | 0.0354 | 0.1084 | 0.1778 |
CPFE formula x ILD extent | –0.0012 | 0.5732 | 0.0000 | 0.4514 | 0.0009 | 0.0161 | 0.0015 | 0.0412 |