Skip to main content

Table 2 Correlation between PFTs and observed emphysema extent (on HRCT) for patients with IPF and emphysema

From: A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema

 

Development cohort

(N = 76)

Clinical trial test cohort

(N = 174)

Real-world test cohort

(N = 110)

R2

P-value

R2

P-value

R2

P-value

CPFE Index

0.55

< 0.0001

0.25

< 0.0001

0.47

< 0.0001

FVC, % predicted

0.14

< 0.001

0.08

0.0001

0.09

0.0012

FEV1, % predicted

0.01

0.53

0.01

0.33

0.001

0.71

Corrected DLco*, % predicted

0.03

0.13

0.01

0.17

0.12

0.0002

FVC/corrected DLco* ratio

0.24

< 0.0001

0.09

< 0.0001

0.45

< 0.0001

  1. CPFE combined pulmonary fibrosis and emphysema; DLco carbon monoxide diffusing capacity; FEV1 forced expiratory volume in 1 s; FVC forced vital capacity;
  2. HRCT high-resolution computed tomography; IPF idiopathic pulmonary fibrosis; PFT pulmonary function test; R2 explained variation/total variation
  3. For R2 of 0 to 1, the closer to 1, the better the regression prediction fits the data
  4. * Corrected for haemoglobin
Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us