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Table 3 Results of Mendelian randomisation analysis for the association of SOMAmers with FEV1

From: Proteomic associations with forced expiratory volume: a Mendelian randomisation study

SOMA

Protein

nSNP

Β—MR

SE

P—MR

FDR P—MR

Egger

Β—Obs

P—Obs

FDR P—Obs

8409_3_3

RSPO2

3

0.109

0.023

2.44 × 10–6

6.27 × 10–4

Yes

− 0.071

6.13 × 10–7

9.17 × 10–5

3339_33_1

THBS2

24

− 0.037

0.009

9.53 × 10–5

8.58 × 10–3

Yes

− 0.054

9.87 × 10–5

3.44 × 10–3

6462_12_3

TIMP4

17

0.028

0.007

1.00 × 10–4

8.58 × 10–3

Yes

− 0.048

6.78 × 10–4

0.012

5353_89_2

IL1RN

3

0.067

0.018

1.44 × 10–4

9.26 × 10–3

Yes

− 0.04

3.56 × 10–3

0.038

8969_49_3

CD14

6

0.084

0.024

5.85 × 10–4

0.03

Yes

− 0.055

4.96 × 10–4

0.01

7994_41_3

ERO1B

12

− 0.025

0.007

8.05 × 10–4

0.034

Yes

− 0.038

4.28 × 10–3

0.042

14125_5_3

APOM

1

0.053

0.016

9.72 × 10–4

0.036

–

0.053

6.65 × 10–5

2.66 × 10–3

8953_47_3

HDGF

7

0.028

0.009

1.26 × 10–3

0.04

Yes

− 0.046

8.38 × 10–4

0.014

2668_70_2

CAPN1

3

− 0.051

0.016

1.94 × 10–3

0.055

Yes

0.049

6.91 × 10–4

0.013

8300_82_3

PEX14

1

− 0.086

0.029

2.70 × 10–3

0.069

–

0.043

1.98 × 10–3

0.025

2828_82_2

SPINT1

3

0.04

0.014

4.73 × 10–3

0.102

Yes

0.041

3.66 × 10–3

0.038

3290_50_2

CD109

49

− 0.013

0.005

4.91 × 10–3

0.102

Yes

0.051

8.83 × 10–5

3.28 × 10–3

2797_56_2

APOB

9

− 0.029

0.011

5.18 × 10–3

0.102

Yes

0.067

7.42 × 10–7

1.04 × 10–4

3580_25_8

SERPINA1

9

− 0.027

0.01

6.03 × 10–3

0.111

Yes

− 0.06

1.68 × 10–5

9.77 × 10–4

13123_3_3

FLRT3

59

− 0.008

0.003

8.97 × 10–3

0.149

Yes

0.044

1.31 × 10–3

0.019

12395_86_3

DARS2

2

− 0.058

0.022

9.64 × 10–3

0.149

–

− 0.038

4.74 × 10–3

0.046

5939_42_3

TNFSF12

77

0.011

0.004

0.01

0.149

Yes

0.042

1.54 × 10–3

0.021

8427_118_3

RSPO3

17

0.033

0.013

0.01

0.149

Yes

− 0.061

3.23 × 10–5

1.63 × 10–3

2630_12_2

IL1RAP

58

0.006

0.002

0.018

0.228

No

0.043

1.05 × 10–3

0.016

7822_11_3

HRASLS2

1

0.071

0.03

0.018

0.228

–

− 0.042

1.70 × 10–3

0.022

5070_76_3

TNFRSF6B

3

0.174

0.075

0.02

0.25

Yes

− 0.052

6.54 × 10–5

2.66 × 10–3

8992_1_3

TMEM2

1

− 0.052

0.023

0.025

0.282

–

0.038

4.33 × 10–3

0.042

8288_27_3

APOH

5

− 0.032

0.014

0.025

0.282

Yes

0.05

2.86 × 10–4

7.12 × 10–3

7803_4_3

CHST1

3

0.035

0.016

0.028

0.304

Yes

− 0.04

3.77 × 10–3

0.039

13130_150_3

HK2

2

− 0.04

0.019

0.032

0.304

–

− 0.039

3.79 × 10–3

0.039

9870_17_3

WARS

5

− 0.021

0.01

0.032

0.304

Yes

0.048

3.23 × 10–4

7.64 × 10–3

4297_62_3

SPON1

8

− 0.026

0.012

0.032

0.304

Yes

− 0.046

1.39 × 10–3

0.019

2789_26_2

MMP7

8

0.02

0.009

0.033

0.304

Yes

− 0.056

4.59 × 10–5

2.13 × 10–3

9172_69_3

MMP8

13

− 0.014

0.007

0.036

0.316

Yes

− 0.041

2.16 × 10–3

0.026

5646_20_3

RNASE6

33

0.008

0.004

0.037

0.316

Yes

− 0.055

5.32 × 10–5

2.29 × 10–3

4546_27_3

ADGRE2

29

0.012

0.006

0.039

0.317

Yes

0.065

1.05 × 10–6

1.29 × 10–4

3449_58_2

SERPINA4

56

− 0.007

0.004

0.039

0.317

Yes

0.038

4.68 × 10–3

0.045

10746_24_3

DKK3

6

− 0.031

0.015

0.044

0.327

Yes

0.063

5.72 × 10–6

4.66 × 10–4

12387_7_3

PDLIM4

11

− 0.025

0.012

0.044

0.327

Yes

0.049

5.60 × 10–4

0.011

5007_1_1

MAPK14

2

− 0.048

0.024

0.048

0.327

–

0.042

1.98 × 10–3

0.025

  1. Shown are data for SOMAmers that had nominally significant (unadjusted p < 0.05) associations using Mendelian randomisation and passed weighted median sensitivity analyses. In the column with results from Egger analyses, “Yes” denotes passing the sensitivity test, “No” denotes failing and “–” denotes insufficient number of SNPs to perform the test. Observational data are adjusted for sex, age, age squared, height and height squared
  2. Bold = Significantly associated with FEV1 in MR analyses after multiple testing correction (FDR < 0.05)
  3. Italic = Consistent in direction between MR analyses and observational analyses
  4. B—MR: Weighted median estimate from the mendelian randomization analysis of the association of the SOMAmer with FEV1
  5. SE: Standard error for the weighted median estimate from the Mendelian randomization analysis of the association of the SOMAmer with FEV1
  6. P—MR: P-value for the weighted median estimate from the Mendelian randomization analysis of the association of the SOMAmer with FEV1
  7. FDR P—MR: False Discovery Rate adjusted p-value for the weighted median estimate from the Mendelian randomization analysis of the association of the SOMAmer with FEV1
  8. B—Obs: Beta estimate from an adjusted linear regression of the association of the SOMAmer with FEV1
  9. P—Obs: P-value from an adjusted linear regression of the association of the SOMAmer with FEV1
  10. FDR P—Obs: False Discovery Rate adjusted p-value from an adjusted linear regression of the association of the SOMAmer with FEV1
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Respiratory Research

ISSN: 1465-993X

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