Table 2 Observational associations of the 25 proteins with the most significant associations for FEV1 as selected by the lowest p-values

3079_62_2

RARRES2

− 0.103

− 0.132 to − 0.074

7.76 × 10^–12

3.71 × 10^–8

8464_31_3

RSPO4

− 0.094

− 0.122 to − 0.067

1.86 × 10^–11

4.44 × 10^–8

7813_6_3

ALPPL2

− 0.087

− 0.113 to − 0.061

1.23 × 10^–10

1.96 × 10^–7

2292_17_4

C9

− 0.084

− 0.109 to − 0.058

3.04 × 10^–10

3.63 × 10^–7

12549_33_3

HPGDS

0.083

0.057 to 0.109

5.12 × 10^–10

4.37 × 10^–7

6605_17_3

IGFALS

0.083

0.057 to 0.109

5.99 × 10^–10

4.37 × 10^–7

12707_26_3

DPYSL3

0.083

0.057 to 0.109

6.40 × 10^–10

4.37 × 10^–7

9191_8_3

TFF2

− 0.084

− 0.111 to − 0.058

7.42 × 10^–10

4.44 × 10^–7

8841_65_3

CILP2

0.082

0.056 to 0.108

1.09 × 10^–9

5.78 × 10^–7

6379_62_3

ADAMTSL2

− 0.088

− 0.116 to − 0.059

3.18 × 10^–9

1.52 × 10^–6

11178_21_3

SVEP1

− 0.082

− 0.11 to − 0.054

1.03 × 10^–8

4.46 × 10^–6

2677_1_1

EGFR

0.075

0.049 to 0.1

1.21 × 10^–8

4.56 × 10^–6

8885_6_3

CACNA2D3

0.077

0.051 to 0.104

1.24 × 10^–8

4.56 × 10^–6

11109_56_3

SVEP1

− 0.081

− 0.109 to − 0.053

1.88 × 10^–8

6.44 × 10^–6

13722_105_3

C9

− 0.073

− 0.099 to − 0.048

2.23 × 10^–8

7.07 × 10^–6

10514_5_3

PTGDS

− 0.086

− 0.116 to − 0.056

2.37 × 10^–8

7.07 × 10^–6

2658_27_1

NTRK3

0.075

0.048 to 0.101

3.67 × 10^–8

1.03 × 10^–5

6390_18_3

NPS

0.078

0.05 to 0.106

4.61 × 10^–8

1.22 × 10^–5

6075_61_3

HEXB

0.076

0.049 to 0.103

6.78 × 10^–8

1.71 × 10^–5

3396_54_2

REN

− 0.075

− 0.102 to − 0.048

7.42 × 10^–8

1.77 × 10^–5

8323_163_3

TFF3

− 0.076

− 0.104 to − 0.048

9.06 × 10^–8

2.06 × 10^–5

2609_59_2

CST3

− 0.081

− 0.111 to − 0.051

1.14 × 10^–7

2.49 × 10^–5

3216_2_2

PIGR

− 0.07

− 0.096 to − 0.044

1.35 × 10^–7

2.81 × 10^–5

4496_60_2

MMP12

− 0.072

− 0.098 to − 0.045

1.52 × 10^–7

3.03 × 10^–5

5632_6_3

CRTAC1

0.074

0.046 to 0.102

1.93 × 10^–7

3.69 × 10^–5