Fig. 4
From: Proteomic associations with forced expiratory volume: a Mendelian randomisation study
Colocalization plot for Thrombospondin-2 (THBS2). Association results for variants in the THBS2 region are shown for FEV1 [29], serum THBS2 protein levels in AGES-Reykjavik [24], and plasma THBS2 protein levels in the deCODE study [32] are shown from top to bottom. Grey circles denote individual SNPs from each study. Both purple diamond and red vertical line represent the lead variant (rs3253, 3’ UTR variant). X-axis is genomic position within chromosome 6 and y-axis is -log10 transformed P-values. Purple horizontal line delineates a genome-wide significance threshold at 5 × 10–8 and yellow vertical lines represent the gene boundary for THBS2. Visualization is restricted to 150,000 bp upstream and downstream of THBS2. Linkage disequilibrium (LD) within the region is plotted at the bottom in green