Table 4 Qualitative and quantitative CT scans
EwAL | GOLD 1 | GOLD 2 | GOLD 3 | A1ATD | P-value | |
|---|---|---|---|---|---|---|
Per-protocol subjects, n | 61 | 122 | 127 | 127 | 19 | |
Qualitative CT | ||||||
Centrilobular emphysema, N (%) | < 0.0001* | |||||
Absent Mild Moderate Confluent Advanced destructive Missing | 36 (59.0) 18 (29.5) 3 (4.9) 1 (1.6) 0 (0.0) 2 (3.3) | 36 (29.5) 37 (30.3) 19 (15.6) 16 (13.1) 11 (9.0) 3 (2.5) | 22 (17.3) 33 (26.0) 22 (17.3) 31 (24.4) 17 (13.4) 2 (1.6) | 7 (5.5) 11 (8.7) 29 (22.8) 34 (26.8) 40 (31.5) 5 (3.9) | 0 (0.0) 2 (10.5) 1 (5.3) 6 (31.6) 8 (42.1) 2 (10.5) | |
Quantitative CT | ||||||
Inspiratory volume, L | 5.80 (1.30) | 6.42 (1.28) | 6.31 (1.35) | 6.63 (1.45) | 8.07 (1.73) | < 0.0001 |
Expiratory volume, L | 2.83 (0.67) | 3.65 (1.01) | 4.01 (1.14) | 4.78 (1.24) | 5.33 (1.51) | < 0.0001 |
PD15, g/L | 91.2 (19.4) | 75.1 (19.0) | 66.2 (22.2) | 47.8 (24.9) | 44.4 (21.1) | < 0.0001 |
ALD, g/L | 88.5 (13.9) | 86.2 (21.4) | 72.4 (21.7) | 54.8 (23.1) | 50.9 (18.2) | < 0.0001 |
LAA-950, % | 3.2 (2.8) | 7.4 (7.2) | 12.7 (9.9) | 21.3 (12.3) | 26.4 (12.0) | |
LAA-856, % | 7.5 (8.4) | 23.0 (14.0) | 36.3 (17.5) | 53.5 (17.2) | 51.3 (19.4) | |
Pi10, mm | 1.8 (0.4) | 2.2 (0.5) | 2.5 (0.5) | 2.6 (0.4) | 2.0 (0.4) | < 0.0001 |
MLD in expiration | − 689.1 (44.6) | − 743.0 (43.5) | − 776.8 (43.9) | − 822.3 (40.5) | − 808.4 (62.1) | < 0.0001 |
FRC/TLC ratio | 0.5 (0.1) | 0.6 (0.1) | 0.6 (0.1) | 0.7 (0.1) | 0.7 (0.1) | < 0.0001 |