Table 3 Post-bronchodilator lung function and lung volume measurements

Per-protocol subjects, n

61

122

127

127

19

Airflow limitation

 FEV₁, L

3.48 (0.77)

2.66 (0.54)

1.97 (0.46)

1.17 (0.29)

1.85 (0.85)

 % predicted FEV₁

102.1 (12.2)

87.4 (9.4)

65.0 (9.7)

39.6 (7.6)

50.4 (20.3)

 FEV₁/FVC, %

78.8 (5.7)

63.4 (5.4)

54.6 (8.6)

38.2 (9.0)

40.6 (13.4)

 FVC, L

4.42 (0.97)

4.22 (0.85)

3.66 (0.90)

3.16 (0.89)

4.54 (1.38)

 % predicted FVC, %

102.2 (10.9)

107.7 (13.2)

93.8 (13.5)

82.6 (15.1)

96.9 (17.6)

Body plethysmography

 TLC, L

6.81 (1.27)

6.70 (1.29)

6.60 (1.44)

7.02 (1.58)

8.16 (1.53)

 RV, L

2.27 (0.54)

2.51 (0.66)

2.91 (0.96)

3.64 (1.02)

3.63 (0.81)

 % predicted RV, %

106.5 (21.3)

111.5 (26.0)

129.0 (38.0)

161.8 (44.4)

163.0 (27.2)

DL_CO

 DL_CO, mmol/min/kPa

  Mean (SD)

11.36 (7.66)

13.34 (8.64)

9.36 (6.52)

7.16 (5.14)

5.19 (2.02)

  Median

8.77

9.28

6.75

5.18

4.78

  Range (Q1–Q3)

4.41

12.83

7.69

5.59

2.34

  % predicted DL_CO

89.2 (16.1)

79.8 (21.3)

63.4 (18.1)

51.5 (17.5)

51.1 (12.7)

DL_CO/VA, mmol/min/kPa

 Mean (SD)

1.88 (1.20)

2.25 (1.36)

1.79 (1.19)

1.61 (1.20)

0.83 (0.19)

 Median

1.38

1.48

1.23

1.04

0.85

 Range (Q1–Q3)

0.43

2.39

1.62

1.83

0.09