Table 2 Symptom questionnaires and 6-min walk test
| Â | EwAL | GOLD 1 | GOLD 2 | GOLD 3 | A1ATD | P-value |
|---|---|---|---|---|---|---|
Per-protocol subjects, n | 61 | 122 | 127 | 127 | 19 | Â |
CAT total score | NA | 11.2 (5.7) | 14.7 (6.2) | 16.6 (7.2) | 13.4 (7.4) |  < 0.0001 |
CAT total score, n (%) | Â | Â | Â | Â | Â | Â |
 < 10  ≥ 10 | NA NA | 45 (36.9) 76 (62.3) | 28 (22.0) 99 (78.0) | 26 (20.5) 101 (79.5) | 7 (36.8) 12 (63.2) | 0.0335* |
mMRC dyspnoea score, n (%) | Â | Â | Â | Â | Â | Â |
 < 2  ≥ 2 | NA NA | 107 (87.7) 14 (11.5) | 86 (67.7) 41 (32.3) | 50 (39.4) 77 (60.6) | 10 (52.6) 9 (47.4) |  < 0.0001* |
SGRQ total score, n (%) | NA | 25.2 (14.4) | 34.7 (15.4) | 43.0 (16.5) | 37.7 (22.3) |  < 0.0001 |
 < 25  ≥ 25  Missing | NA NA | 58 (47.5) 62 (50.8) 2 (1.6) | 38 (29.9) 88 (69.3) 1 (0.8) | 20 (15.7) 106 (83.5) 1 (0.8) | 5 (26.3) 14 (73.7) 0 (0.0) |  < 0.0001* |
SGRQ activity score | NA | 35.6 (20.2) | 48.9 (20.0) | 60.1 (18.3) | 54.8 (28.1) |  < 0.0001 |
SGRQ impacts score | NA | 17.0 (13.3) | 24.0 (16.4) | 32.8 (17.9) | 27.2 (21.8) |  < 0.0001 |
SGRQ symptoms score | NA | 33.3 (19.4) | 42.8 (19.1) | 44.9 (22.5) | 40.2 (22.5) | 0.0020 |
Total distance covered in 6 MWT, m | 573.1 (100.3) | 489.3 (91.7) | 458.0 (101.3) | 403.8 (121.7) | 508.6 (114.4) |  < 0.0001 |