Fig. 4
From: Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
Amitriptyline strongly improves lung function in obstructive lung disease. A Resistance in mouse IPL after systemic or B intratracheal treatment with amitriptyline (1 µM Ami in perfusat medium and 67 µg in 50 µl intratracheally). C Total resistance and D tissue resistance in wildtype mice after pre-inhalation with amitriptyline and following ventilation with the flexiVent setup. A, C, D n = 6 in both groups. B n = 4 in both groups. All graphs represent means ± SEM; *p < 0.05, ***p < 0.001