Fig. 3
From: Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
Amitriptyline clearly reduces the effect of different mediators of bronchoconstriction in rat, guinea pig and human PCLS. A Concentration–response curves of rat PCLS stimulated with serotonin, B endothelin and C U46619. D Concentration–response curves of PCLS of guinea-pigs and E humans stimulated with histamine. F Concentration–response curves of guinea-pig PCLS stimulated with LTD4. A–F Pre-incubation with amitriptyline in rising concentrations. Rats: n = 6 in all groups, guinea pigs: n = 7 in all groups, humans: controls and Ami 1 µM: n = 6; Ami 0.1 and 5 µM: n = 9. All graphs represent means ± SEM; *p < 0.05