Fig. 1
From: Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
Amitriptyline inhibits acetylcholine-induced airway constriction. A Concentration–response curves of acetylcholine-stimulated PCLS of rats and B mice pre-treated with different concentrations of amitriptyline (0–5 µM). C Exemplary cycles of electric field stimulation (EFS) in rat PCLS with saline and D amitriptyline-treatment. Neostigmin was used as stabilisator of bronchoconstriction. E Minimal airway area in EFS experiments with amitriptyline. F Acetylcholine-induced airway constriction in mouse PCLS pre-treated with fluoxetine. A, B All groups n = 6. E, F Controls n = 4, all other groups n = 6. A, B, E, F All graphs represent means ± SEM; *p < 0.05, **p < 0.01