Table 3 Functional, laboratory, and hemodynamic parameters before and after BPA

Pre-BPA

Post-BPA

p value

Pre-BPA

Post-BPA

p value

WHO functional class (I/II/III/IV)

1/4/16/1

4/17/1/0

< 0.001

0/16/35/2

12/38/3/0

< 0.001

6-min walk distance, m (n = 56)

336 (300–434)

480 (389–515)

0.004

389 (334–464)

461 (396–536)

< 0.001

BNP, pg/ml (n = 74)

32 (13–105)

12 (9–21)

0.011

119 (57–375)^*

26 (15–55)^**

< 0.001

Mean PAP, mmHg

40 ± 7

25 ± 8

< 0.001

41 ± 9

24 ± 6

< 0.001

CI, l/min/1.73m²

2.9 ± 1.0

2.9 ± 0.6

0.984

2.7 ± 0.7

2.8 ± 0.6

0.288

PVR, dyne∙s∙cm^− 5

491 (376–654)

215 (175–261)

< 0.001

667 (435–792)

229 (170–350)

< 0.001

SaO₂, %

87.9 ± 4.9

92.8 ± 5.2

0.002

90.9 ± 4.1^*

94.3 ± 3.2

< 0.001

SvO₂, %

64.4 ± 5.3

69.3 ± 8.9

0.005

62.7 ± 9.4

70.8 ± 5.8

< 0.001

 A-aDO₂, mmHg (n = 68)

45 ± 9

27 ± 13

< 0.001

42 ± 10

26 ± 11

< 0.001