Table 2 Baseline functional, laboratory, hemodynamic, and respiratory parameters

Symptom and exercise capacity

Duration from symptom to diagnosis < 1 year, n (%)

11 (50.0)

30 (56.6)

0.601

WHO functional class (I/II/III/IV)

1/4/16/1

0/16/35/2

0.321

6-min walk distance, m (n = 65)

336 (306–429)

387 (320–455)

0.283

Laboratory parameters

Hemoglobin, g/dl

13.8 ± 1.5

13.5 ± 1.7

0.435

BNP, pg/ml

32 (13–105)

117 (54–373)

0.001

Hemodynamic data

Heart rate, bpm

74 ± 13

78 ± 15

0.415

Mean RAP, mmHg

7 ± 2

7 ± 3

0.725

Mean PAP, mmHg

40 ± 7

41 ± 9

0.477

Mean PCWP, mmHg

9 ± 3

9 ± 3

0.373

Mean blood pressure, mmHg

82 ± 13

89 ± 16

0.086

SaO₂, %

87.9 ± 4.9

90.9 ± 4.1

0.009

SvO₂, %

64.4 ± 5.3

62.7 ± 9.4

0.745

CO, l/min

5.1 ± 1.6

4.3 ± 1.1

0.116

CI, l/min/1.73m²

2.9 ± 1.0

2.7 ± 0.7

0.565

PVR, dyne∙s∙cm^− 5

491 (376–654)

667 (435–792)

0.066

Respiratory function

Percent vital capacity, % (n = 70)

89.9 ± 16.2

92.5 ± 13.6

0.511

FEV_1.0%, % (n = 70)

73.7 ± 9.6

72.8 ± 10.3

0.781

%DLCO, % (n = 70)

75.1 ± 13.1

82.5 ± 16.4

0.074

 A-aDO₂, mmHg (n = 72)

46 ± 9

42 ± 10

0.103