Fig. 3
From: Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
Differential expression between IPF and controls with histologically normal lung tissue in normal appearing lung parenchyma (A). Top 15 Ingenuity canonical pathways in the IPF vs. control normal lung parenchyma comparison (B). The activation z-score is a statistical measure based on the directional relationships between genes and their biological function. Orange indicates increased predictions over that of the null (positive z score), blue indicates decreased predictions (negative z score) and white z score of zero. Differential expression between IPF and controls with histologically normal lung tissue in normal bronchiolar regions (C) adjusting for batch and estimated cell proportions of AEC1, AEC2, fibroblasts and ciliated cells