Fig. 2
From: Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
Mean cell proportions estimated with SpatialDecon based on IPF cell reference (A). Histology image showing changes in alveolar cell composition (B). Immunofluorescence changes in SFTPC and AGER between IPF and controls with histologically normal lung tissue in normal parenchyma regions (C). FOVs were chosen based on presence of features of interest (e.g. parenchyma, bronchiolar, etc.) in each section and 9 20x images centered randomly within the feature of interest were assembled into a composite. Pairwise comparisons are Mann-Whitney U test with significance set to (*) p < 0.05, (**) p < 0.01, (***) p < 0.001, (****) p < 0.0001