Fig. 5
From: [18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload
FAPI signal in RV is progressively increased from PAB rats by [18 F] -FAPI-42 PET/CT imaging. (A) Representative [18 F] -FAPI-42 PET/CT images in right heart. Similar with the sham rats, no significant [18 F] -FAPI-42 uptake was observed at day 3 or week 1 after PAB. Pressure overload resulted in increased FAPI signal from week 2 to week 8 after PAB by [18 F] -FAPI-42 PET/CT. (B) SUVR of [18 F] -FAPI-42 in the right heart from sham and PAB rats. (C)-(D) The intensity of [18 F] -FAPI PET in right heart directly correlated with the FAP immunofluorescence (C) and the RV fibrosis detected by Masson’s trichrome staining (D). n= (5/group), ns = not significant, **p < 0.01, ***p < 0.001, compared with sham group. ##p < 0.01, compared with the indicated time point of PAB group. SUVR = ratios of standardized uptake value, R = right, L = left, PAB = pulmonary artery banding group, sham = sham group