Fig. 4
From: [18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload
Immunofluorescence staining reveals that FAP is progressively increased in RV with the duration pressure overload. (A) Representative FAP immunofluorescence pictures of RV from sham or PAB rats (day 3, week 1, week 2, week 4 and week 8). FAP (green) = Fibroblast Activation Protein; DAPI (blue) = 4′,6 -diamidino-2-phenylindole. (B) Quantitative analysis of FAP-positive area in RV: no significant increase of FAP-positive cells in early PAB (day 3 and week 1 after surgery), FAP began to be detected at week 2 and progressively increased until the end of the experiment (week 8). ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001, compared with sham group. ##p < 0.01, compared with the indicated time point among PAB group. n= (5–7/group), bar = 25 μm, PAB = pulmonary artery banding group, sham = sham group