Fig. 3
From: [18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload
RNA sequencing indicates that myocardial fibrosis is a critical process in RV lesions in PAB rats. (A)-(B) Venn diagram demonstrating differentially expressed genes (DEGs) in the RV tissue between PAB and sham rats at week 2 and week 4, indicating 329 and 544 up-regulated genes at week 2 and 4 respectively (A), 330 and 733 down-regulated genes at week 2 and 4 respectively (B) (FC cut-offs > 1.2 or < 0.83333). (C)-(D) Heatmap illustrating the overlapped DEGs from week 2 and week 4, indicating 80 up-regulated genes (C) and 43 down-regulated genes (D) at both time points. (E) The top 20 GO (Gene Ontology) items of the overlapped upregulated genes are displayed and the GO items of extracellular matrix and fibrosis are most significantly enriched in the RV from PAB rats. (F) The GO analysis on the overlapped downregulated genes. PAB = pulmonary artery banding group, sham = sham group