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Fig. 3 | Respiratory Research

Fig. 3

From: Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis

Fig. 3

Median PD-1 mRNA expression was significantly higher in lymph nodes isolated from mice treated with bleomycin compared to littermates treated with saline at day 14 (Mann-Whitney test; p = 0.009), (Panel A). Median PD-L1 mRNA expression was significantly higher in lymph nodes isolated from mice treated with bleomycin compared to littermates treated with saline at day 14 (Mann-Whitney test; p = 0.002), (Panel B). Median CD4/CD8 ratio was significantly higher in mediastinal lymph nodes isolated from mice treated with bleomycin compared to littermates treated with saline at day 14 (Mann-Whitney test; p = 0.002), (Panel C). Median CD4+/PD-1 + double positive cells percentage out of CD45 + cells was significantly higher in mediastinal lymph nodes isolated from mice treated with bleomycin compared to littermates treated with saline at day 14 (Mann-Whitney test; p = 0.026), (Panel D). The size (mm2) of lymph nodes isolated from mice treated with bleomycin was significantly increased compared to saline-treated mice at day 14 (Mann-Whitney test; p = 0.002), (Panel E). Representative images of lymph nodes isolated from mice treated with bleomycin and littermates treated with saline at day 14 (Panel F). Six mice were used in each arm (two independent experiment of three mice per arm, each, total mice: 12)

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Respiratory Research

ISSN: 1465-993X

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