Fig. 8
From: Targeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats
Effect of SR9009 on mitogen-activated protein kinase (MAPK) activation in lung tissues. The phosphorylation of ERK (A), JNK (B), and p38 (C) exhibited an increase in the ischemia-reperfusion (IR) group. However, the treatment with SR9009 effectively attenuated these effects. On the other hand, the addition of SR8278 negated the protective effect of SR9009. A representative blot is provided. The data are presented as mean ± SD (n = 3 per group). *p < 0.05, **p < 0.01,***p < 0.001, compared to control group; +p < 0.05, ++p < 0.01, +++p < 0.001, compared to IR group; #p < 0.05, ##p < 0.01, compared to IR + SR9009 50 mg group