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Fig. 4 | Respiratory Research

Fig. 4

From: Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models

Fig. 4

TGF-β receptor activation is necessary and sufficient to induce ET-1 secretion. Pretreatment with SB431542 attenuated compression-induced EDN1 expression A and ET-1 secretion (B). **p < 0.01, ****p < 0.0001 vs vehicle; ##p < 0.01 vs compression alone. rhTGF-β1 (10 ng/ml) induced EDN1 expression C and ET-1 secretion D *p < 0.05 vs vehicle. Each data point represents the mean of duplicate transwells of differentiated HBE cells from each donor (mean ± SD; A, B: n = 3 distinct donors, C, D: n = 6 distinct donors)

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Respiratory Research

ISSN: 1465-993X

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