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Fig. 3 | Respiratory Research

Fig. 3

From: Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models

Fig. 3

RV-induced ET-1 secretion depends on the activation of the TGF-β receptor. Pretreatment with SB431542 attenuated RV-induced EDN1 expression (A) and ET-1 secretion (B). **p < 0.01 and ***p < 0.001 vs vehicle; #p < 0.05 vs RV alone. Pretreatment with SB431542 decreased poly(I:C)-induced EDN1 expression (C) and ET-1 secretion (D). ****p < 0.0001 vs vehicle; ###p < 0.001 vs poly(I:C) alone. Each data point represents the mean of duplicate transwells of differentiated HBE cells from each donor (mean ± SD; A, B: n = 4 distinct donors, C, D: n = 5 distinct donors)

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Respiratory Research

ISSN: 1465-993X

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