Fig. 1
From: Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy
Time course of EETosis. Many ex vivo and in vivo stimuli can lead to human eosinophil activation, increased intracellular Ca2 + and reactive oxygen species production, PAD4-mediated citrullination of nucleosomal histones, resulting in chromatin decondensation with nuclear rounding. Additionally, there is galectin-10 redistribution and occasional formation of intracellular CLCs prior to plasma membrane lysis. Finally, both nuclear and plasma membranes are disassembled, and reticulated chromatin structures are released. EETosis: Eosinophil extracellular trap cell death; PAD4: Peptidyl arginine deaminase 4; CLCs: Charcot-Leyden crystals; EETs: Eosinophil extracellular traps