Fig. 2
From: CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
At baseline, smooth muscle-specific CFTR knockout mice (Cftrfl/fl; SM-Cre mice) showed no abnormalities in lung morphology or pulmonary resistance. A. Trichrome stain of lung sections from Cftrfl/fl; SM-Cre mice, which lack CFTR function in smooth muscle, do not reveal abnormalities at baseline compared to control Cftrfl/fl lung sections. B. Staining and morphometric analysis of airway smooth muscle (ASM) with αSMA immunohistochemistry demonstrates similar ASM burden in Cftrfl/fl; SM-Cre and control mice. C. Baseline lung resistance is unchanged by loss of CFTR function in ASM. D. Methacholine challenge of Cftrfl/fl; SM-Cre and Cftrfl/fl mice show no increased airway hyperreactivity (AHR) with loss of CFTR function in smooth muscle. Data are presented as mean ± SD