Fig. 1
From: CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity
Graphical summary of this study. A. At baseline, smooth muscle-specific knockout mice Cftrfl/fl; SM-Cre mice) do not demonstrate altered lung mechanics or lung morphology compared to control Cftrfl/fl mice. B. Three days after exposure to Ad-TGFβ or empty vector control, Cftrfl/fl; SM-Cre mice had similar pulmonary inflammation and lung morphology (goblet cell hyperplasia and ASM area) compared to control mice. However, only Cftrfl/fl; SM-Cre mice developed elevated AHR after TGFβ treatment. This study demonstrates that loss of CFTR function in smooth muscle contributes to CF airway obstruction mediated by TGFβ. Created with BioRender.com