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Table 5 Univariable and multivariable linear regression analysis of early and current life factors and proteins of interest in POLD compared to PTc

From: Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children

Variable

MMP9

S100A8

CTSC

Beta

SE

p-value

Beta

SE

p-value

Beta

SE

p-value

Univariable Models

Sex, ref = Male

0.15

0.10

0.15

-0.42

0.26

0.11

-0.02

0.13

0.88

Age at testing, years

-0.01

0.04

0.72

-0.04

0.09

0.65

0.01

0.05

0.78

IUGR ref = No IUGR

-0.02

0.13

0.90

0.32

0.34

0.36

-0.10

0.17

0.55

BPD ref = No BPD

-0.26

0.11

0.017*

0.38

0.28

0.17

-0.03

0.15

0.85

POLD ref = PTc

-0.30

0.13

0.025*

-0.69

0.34

0.043*

-0.31

0.16

0.058

Multivariable Models

BPD ref = No BPD

-0.26

0.11

0.017*

Not taken forward

for multivariable model

Not taken forward

for multivariable model

POLD ref = PTc

-0.30

0.13

0.024*

  1. SE: Standard error; IUGR: Intrauterine growth restriction; BPD: Bronchopulmonary dysplasia, POLD: prematurity-associated obstructive lung disease, PTc: preterm-born controls. Multivariable models only created where ≥ 2 univariable models had a p-vale < 0.1
  2. Bold*: p value < 0.05 Italic: p value < 0.1