Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children

Respiratory Research

Table 4 Univariable and multivariable linear regression analysis of early and current life factors and proteins of interest in pPRISm compared to PT_c

Variable	DNASE1			PGLYRP1			B2M			SERPINA3
Variable	Beta	SE	p-value	Beta	SE	p-value	Beta	SE	p-value
Univariable Models
Sex, ref = Male	0.14	0.17	0.39	0.21	0.13	0.11	0.14	0.22	0.52	0.13	0.10	0.22
Age at testing, years	-0.07	0.06	0.23	0.05	0.05	0.32	-0.08	0.08	0.30	0.03	0.04	0.44
IUGR ref = No IUGR	-0.11	0.26	0.68	-0.34	0.21	0.09	-0.28	0.34	0.41	0.15	0.17	0.40
BPD ref = No BPD	-0.32	0.18	0.08	-0.24	0.14	0.10	-0.67	0.23	0.005*	0.07	0.12	0.54
POLD ref = PT_c	-0.53	0.21	0.011*	-0.40	0.16	0.016*	-0.60	0.27	0.027*	-0.37	0.13	0.005*
Multivariable Models
IUGR ref = No IUGR	-	-	-	-0.38	0.20	0.06	-	-	-	Not taken forward for multivariable model
BPD ref = No BPD	-0.33	0.18	0.06	-	-	-	-0.69	0.23	0.003*
pPRISm ref = PT_c	-0.55	0.20	0.008*	-0.42	0.16	0.011*	-0.63	0.26	0.018*

SE: Standard error; IUGR: Intrauterine growth restriction; BPD: Bronchopulmonary dysplasia, pPRISm: prematurity-associated preserved ratio-impaired spirometry, PT_c: preterm-born controls
Bold*: p value < 0.05 Italic: p value < 0.1. Dashes indicate variables that had p ≥ 0.1 on univariable analysis and therefore not included in multivariable model. Multivariable models only created where ≥ 2 univariable models had a p-value < 0.1

ISSN: 1465-993X