Table 3 ROC Analysis of high replicate proteins implicated in related biological functions by IPA software. POLD: Prematurity-related obstructive lung disease. pPRISm: Prematurity-related preserved ratio with impaired spirometry. PTc: Preterm-born controls. CI: Confidence Interval. PPV: Positive predictive value. NPV: Negative predictive value
From: Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children
Protein(s) included in model | Replicates | AUC (95% CI) | p-value | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|---|
pPRISm vs. PT c (n = 27 v 112) | |||||||
DNASE1 | 27 v 112 | 0.66 (0.55, 0.78) | 0.004 | 0.56 (0.37, 0.74) | 0.72 (0.64, 0.80) | 0.33 (0.19, 0.46) | 0.87 (0.80, 0.94) |
PGLYRP1 | 27 v 112 | 0.64 (0.53, 0.75) | 0.012 | 0.93 (0.83, 1.00) | 0.32 (0.23, 0.40) | 0.25 (0.16, 0.33) | 0.95 (0.87, 1.02) |
B2M | 27 v 112 | 0.63 (0.51, 0.75) | 0.020 | 0.59 (0.41, 0.78) | 0.66 (0.60, 0.75) | 0.30 (0.18, 0.42) | 0.87 (0.80, 0.94) |
SERPINA3 | 25 v 100 | 0.66 (0.53, 0.79) | 0.007 | 0.48 (0.28, 0.68) | 0.82 (0.75, 0.90) | 0.40 (0.23, 0.58) | 0.86 (0.79, 0.93) |
DNASE1 + PGLYRP1 + B2M + SERPINA3 | 25 v 100 | 0.73 (0.61, 0.84) | < 0.001 | 0.80 (0.64, 0.96) | 0.73 (0.64, 0.82) | 0.43 (0.28, 0.57) | 0.94 (0.88, 0.99) |
POLD vs. PT c (n = 21 v 112) | |||||||
S100A8 | 21 v 107 | 0.64 (0.52, 0.76) | 0.021 | 0.82 (0.66, 0.98) | 0.50 (0.40, 0.59) | 0.25 (0.15, 0.35) | 0.93 (0.86, 1.00) |
MMP9 | 21 v 105 | 0.64 (0.51, 0.77) | 0.023 | 0.48 (0.26, 0.69) | 0.76 (0.68, 0.84) | 0.29 (0.14, 0.44) | 0.88 (0.81, 0.95) |
CTSC | 19 v 77 | 0.66 (0.53, 0.79) | 0.015 | 0.68 (0.48, 0.89) | 0.65 (0.54, 0.76) | 0.33 (0.18, 0.47) | 0.89 (0.81, 0.97) |
S100A8 + MMP9 + CTSC | 19 v 77 | 0.76 (0.63, 0.90) | < 0.001 | 0.84 (0.68, 1.00) | 0.61 (0.50, 0.72) | 0.35 (0.21, 0.49) | 0.94 (0.87, 1.00) |