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Table 2 Significantly altered biological processes in pPRISm & POLD vs. PTc identified by IPA software

From: Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children

Gene Name

Protein Name

Protein Function

Protein ID FDR

Replicates

Log2FC

p-value

Inflammation of body cavity

Apoptosis myeloid cells

Quantity of leucocytes

Quantity of T-lymphocytes

Quantity of CD4 + T-lymphocytes

Quantity of CD8 + T-lymphocytes

Accumulation of neutrophils

pPRISm vs. PTc

(n = 27 vs. 112)

GLA

Alpha-galactosidase A

Lipid metabolism

0.002

2 v 6

-1.06

0.0001

  

●

    

CLEC11A

C-type lectin domain family 11 member A

Osteogenesis

0.01

3 v 15

-1.39

0.001

  

●

    

NAGLU

Alpha-N-acetylglucosaminidase

Glycosidase/

hydrolase

< 0.001

25 v 107

-0.34

0.011

●

      

PGLYRP1

Peptidoglycan recognition protein 1

Innate immunity

< 0.001

27 v 112

-0.40

0.012

●

 

●

●

●

  

DNASE1

Deoxyribonuclease-1

Serum endonuclease

< 0.001

27 v 112

-0.53

0.013

●

 

●

●

●

●

 

MYH9

Myosin-9

Cell adhesion/shape

< 0.001

4 v 8

0.49

0.014

●

      

SERPINA3

Alpha-1-antichymotrypsin

Serine protease inhibitor

< 0.001

25 v 100

-0.36

0.014

●

●

     

CTSV

Cathepsin L2

Thiol protease

0.035

16 v 73

-0.33

0.015

●

 

●

●

●

  

AGT

Angiotensinogen

(Serpin A8)

Regulation of blood pressure

< 0.001

4 v 28

0.81

0.019

●

 

●

●

 

●

 

ANXA1

Annexin A1

Inflammatory/immune response

< 0.001

7 v 29

1.46

0.026

●

●

●

●

●

●

 

CLEC4G

C-type lectin domain family 4 member G

Substrate binder

< 0.001

27 v 106

-0.36

0.028

●

 

●

●

●

●

 

SCGB1A1

Uteroglobin

Phospholipase A2 inhibitor

< 0.001

5 v 33

-1.04

0.032

●

 

●

    

MGAM

Maltase-glucoamylase

Carbohydrate metabolism

< 0.001

27 v 112

-0.35

0.038

●

      

B2M

Beta-2-microglobulin

Class I major histocompatibility complex

< 0.001

27 v 112

-0.60

0.040

●

 

●

●

 

●

 

ANPEP

Aminopeptidase N

Aminopeptidase

< 0.001

23 v 103

-0.37

0.040

 

●

●

●

●

  

CD14

Monocyte differentiation antigen CD14

Inflammatory/immune response

< 0.001

27 v 112

-0.39

0.045

●

●

     

POLD vs. PT c

(n = 21 vs. 112)

MMP9

Matrix metalloproteinase-9

Collagen degradation, leukocyte migration

< 0.001

21 v 105

0.30

0.018

      

●

AGT

Angiotensinogen

(Serpin A8)

Regulation of blood pressure

< 0.001

5 v 28

0.55

0.030

      

●

S100A8

Protein S100-A8

Inflammatory/immune response

< 0.001

21 v 107

0.69

0.034

      

●

CTSC

Dipeptidyl peptidase 1 (Cathepsin C)

Thiol protease

< 0.001

19 v 77

0.31

0.038

      

●

  1. Protein ID FDR: Protein identification false discovery rate; measure of confidence for the correct identification of the protein. Log2FC: log2 fold change of protein abundances between groups. p values given by Welch’s t-test
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Respiratory Research

ISSN: 1465-993X

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