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Table 1 Sample Demographics

From: Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children

Variable

Term born (\(\ge\)37/40)

n = 46

Preterm born (\(\le\)34/40)

n = 160

Preterm born Controls

n = 112

pPRISm

n = 27

POLD

n = 21

Sex (male), n(%)

23 (50.0)

76 (47.5)

52 (46.4)

17 (63)

7 (33.3)

Ethnicity (white), n(%)

45 (97.8)

152 (95)

105 (93.8)

27 (100)

20 (95.2)

Age at testing (years), mean (SD)

9.9 (1.1)

10.4 (1.4)*

10.4 (1.3)

10.6 (1.6)

10.1 (1.7)

Weight (kg), mean (SD)

36.3 (10.3)

35.9 (9.7)

36.4 (9.5)

35.5 (9.1)

33.9 (11.8)

Body Mass Index (kg/m2), mean (SD)

18.1 (3.2)

17.5 (3.1)

17.7 (3.0)

17.0 (2.9)

17.0 (3.9)

Wheeze-ever, n(%)

12 (26.1)

97 (56.9)***

64 (57.1)

15 (55.6)

18 (85.7)†#

Doctor-diagnosed asthma, n(%)

2 (4.3)

39 (24.4)**

21 (18.8)

7 (25.9)

11 (52.4)††

Neonatal Characteristics

Gestational age (weeks), mean (SD)

40.1 (1.2)

30.5 (2.8)***

30.4 (2.9)

30.9 (2.9)

30.2 (2.5)

Birthweight (g), mean (SD)

3499 (576)

1549 (594)***

1577 (607)

1587 (543)

1352 (572)

Birthweight (z-score), mean (SD)

0.1 (0.99)

0.11 (1.37)

0.3 (1.42)

-0.12 (0.9)

-0.45 (1.46)

Intrauterine growth restriction, n(%)

3 (6.5)

25 (15.6)

15 (13.4)

2 (7.4)

8 (38.1)††##

Antenatal Steroids, n(%)

0 (0)

137 (85.6)***

99 (88.4)

22 (81.5)

16 (76.2)

Mechanical ventilation, n(%)

0 (0)

70 (43.8)***

53 (47.3)

7 (25.9)

10 (47.6)

Bronchopulmonary Dysplasia (BPD), n(%)

0 (0)

47 (29.2)***

34 (30.4)

7 (25.9)

6 (28.6)

Antenatal smoking, n(%)

3 (6.5)

22 (13.8)

16 (14.3)

4 (14.8)

2 (9.5)

  1. Preterm vs. Term: *p < 0.05, **p < 0.01, ***p < 0.001. pPRISm/POLD vs. Preterm born control: †p < 0.05, ††p < 0.01, †††p < 0.001. pPRISm vs. POLD: #p < 0.05, ##p < 0.01
  2. pPRISm: Prematurity-related preserved ratio with impaired spirometry. POLD: Prematurity-related obstructive lung disease. BPD: Bronchopulmonary dysplasia.