Fig. 2
CIH increased Methacholine reactivity expressed primarily in the distal airway. The maximal responses (reactivity) for respiratory system resistance (Rrs) (A) and elastance (Ers) (B), Newtonian resistance (RN) (C) and tissue damping (G) (D) recorded across Methacholine concentrations of 0, 4, 8, 16, 32, 64 and 128 mg/mL. HDM/CIH group significantly different vs.: *SAL/NORM, †SAL/CIH and ‡HDM/NORM (all p < 0.05); HDM/CIH group trends relative to §SAL/CIH and #HDM/NORM (p = 0.056 for each comparison); (2-way [RM] ANOVA and Holm-Sidak post-hoc tests for group comparisons). Data presented as mean ± SEM. N = 10–12 rats/group