Fig. 7From: Metformin attenuates chronic lung allograft dysfunction: evidence in rat modelsTherapeutic effects and potential molecular mechanisms of metformin in CLAD. Metformin attenuates the progression of CLAD and exerts anti-fibrotic and immunomodulatory effects in rat recipients receiving MHC-mismatched LTx. The alterations of AMPK activity in different cells were the potential molecular mechanismBack to article page