Fig. 2
From: Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
Metformin attenuates chronic lung allograft rejection in rat lung transplantation. a Macroscopic images of the whole lung and microscopic (hematoxylin–eosin [HE] and Masson’s trichrome [MT] staining; objective magnification, 10 × or 40 ×) images of the lung graft lung parenchyma. Yellow arrows denote lung grafts. Gamma: 1.0. b Assessment of ISHLT C grade. Kruskal–Wallis test followed by Dunnett’s multiple comparisons test, *P, 0.05. Semiquantitative analysis of typical pathological changes of CLAD, including percentage of obliterative bronchioles, percentage of parenchymal fibrosis, pleural thickness. One-way analysis of variance (one-way ANOVA) followed by Tukey’s multiple test, *P, 0.05, **P, 0.01. (n = 6 rats / group)