Fig. 1
From: Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
Treatment protocols. Syngeneic (donor: Lewis rats, recipient: Lewis rats) and allogeneic donor: Brown Norway rats, recipients: Lewis rats) orthotopic left lung transplantation (LTx) was performed in our study. Rats were randomized into four groups: the Syngeneic, Allograft-Cyclosporine A (Allo-CsA), Allograft-Normal saline (Allo-NS group), and Allograft-Metformin groups. Treatment intervention protocols from posttransplant week 1 to week 4 were summarized. During posttransplant week 1, NS was administered in syngeneic LTx recipients, while CsA was administered to allogeneic LTx recipients. From posttransplant week 2 to week 4, NS was administered in the Syngeneic and Allo-NS groups, CsA was consistently administered in the Allo-CsA group, and metformin was administered in the Allo-Metformin group. Vehicles administration was comparable in each group